RecruitingPhase 1NCT06700811
Neurological
West Syndrome
Also known as Infantile spasms, IS, hypsarrhythmia with epileptic spasms
West syndrome (infantile spasms) is an age-specific severe epileptic encephalopathy defined by the triad of epileptic spasms (clusters of brief flexion or extension jerks), hypsarrhythmia on EEG (chaotic high-voltage slow waves with multifo
ORPHA:3451 ↗Gene Multiple (CDKL5Gene ARXGene STXBP1Gene TSC1/TSC2 and others)Prevalence 1-5 per 10,000 (Orphanet)Onset InfantileMultiple etiologies (structural, genetic, metabolic, unknown)
9
studies recruiting now
as of 7 Sept 2026
106
studies registered in total
as of 7 Sept 2026
4
countries with a recruiting site
as of 7 Sept 2026
22 Jan 2026
most recent study posted
among recruiting studies
Recruiting trials
RecruitingPhase 2NCT04289467
Treatment of Refractory Infantile Spasms With Fenfluramine
RecruitingNCT05126914
Multicentre Real-life Follow-up Study of Rare Epileptic Syndromes in Children and Adolescents
RecruitingNCT07358910
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
RecruitingPhase 4NCT07160075
HIV Prevention With PrEP Among People on Opioid Replacement Therapy
Showing the 5 most recently updated recruiting studies, as recorded 7 Sept 2026. Live status on each study page.
See all 9 recruiting studiesWhere recruiting studies are running
Countries with at least one recruiting site among the studies above, 7 Sept 2026. Tap a country to search trials there.
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About West Syndrome
West syndrome (infantile spasms) is an age-specific severe epileptic encephalopathy defined by the triad of epileptic spasms (clusters of brief flexion or extension jerks), hypsarrhythmia on EEG (chaotic high-voltage slow waves with multifocal spikes), and developmental arrest or regression. Onset peaks between 4-8 months of age. ACTH and vigabatrin are established first-line treatments; early treatment initiation is critical for developmental outcomes.
Common clinical features
Epileptic spasms in clustersHypsarrhythmia on EEGDevelopmental arrest or regressionHead dropsArm extension and flexion jerksIrritabilityLoss of social smile
From Orphanet’s phenotype annotations (CC BY 4.0). Not a complete list.
Treatments being studied
3 approved treatments and 7 in clinical development, from Open Targets (CC BY 4.0). Not medical advice.
Approved: Ganaxolone (Ztalmy)Approved: Corticotropin (Acth)Approved: Vigabatrin (Kigabeq)
Phase 3Prednisolone (Cortalone)
Phase 3Cannabidiol (Epidiolex)
Phase 3Pyridoxine (Pyridoxine component of vitaped)
Phase 2Radiprodil
Phase 1Cpp-115
Phase 1Blarcamesine Hydrochloride (Anavex)
Phase 1Blarcamesine (Anavex)
Before you apply
Things trial teams commonly ask about for West Syndrome. Not eligibility rules; those are set by each study.
- EEG-confirmed hypsarrhythmia and video-EEG documentation of spasm clusters are required for trial enrollment
- Age at spasm onset and time from onset to treatment initiation affect prognosis and trial eligibility windows
- Prior ACTH or vigabatrin treatment response history is a critical eligibility factor
- Underlying etiology (TSC, genetic, structural, cryptogenic) determines eligibility for etiology-specific trials versus general infantile spasm trials
Related conditions
Information, not medical advice. Trial listings are shown as recorded on ClinicalTrials.gov; whether any study is right for you is a decision for you and your clinicians, and eligibility is decided by each research team. Disease information from Orphanet (CC BY 4.0).