RecruitingNCT06596746
Neurological
Corticobasal Degeneration
Also known as CBD, corticobasal syndrome, CBS, corticobasal ganglionic degeneration
Corticobasal degeneration is a rare 4-repeat tauopathy causing neuronal loss and tau accumulation in the cortex and basal ganglia. The corticobasal syndrome (CBS) clinical presentation includes asymmetric limb rigidity and apraxia, the alie
ORPHA:37596 ↗Gene MAPT (risk haplotypeGene GRN rarely)Prevalence 1-9 per 100,000 (Orphanet)Onset AdultSporadic (MAPT risk haplotype)
19
studies recruiting now
as of 7 Sept 2026
62
studies registered in total
as of 7 Sept 2026
4
countries with a recruiting site
as of 7 Sept 2026
3 Jun 2025
most recent study posted
among recruiting studies
Recruiting trials
RecruitingNCT03225144
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
RecruitingNCT04363684
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
RecruitingNCT07000851
Imaging Studies in Corticobasal Syndrome
RecruitingNot applicableNCT03174938
The Swedish BioFINDER 2 Study
Showing the 5 most recently updated recruiting studies, as recorded 7 Sept 2026. Live status on each study page.
See all 19 recruiting studiesWhere recruiting studies are running
Countries with at least one recruiting site among the studies above, 7 Sept 2026. Tap a country to search trials there.
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About Corticobasal Degeneration
Corticobasal degeneration is a rare 4-repeat tauopathy causing neuronal loss and tau accumulation in the cortex and basal ganglia. The corticobasal syndrome (CBS) clinical presentation includes asymmetric limb rigidity and apraxia, the alien limb phenomenon, cortical sensory loss, myoclonus, and dystonia. CBD is pathologically defined at autopsy; clinically it overlaps with PSP, frontotemporal dementia, and Parkinson's disease. Disease progression is relentless with no approved therapies.
Common clinical features
Asymmetric limb rigidityApraxiaAlien limb phenomenonCortical sensory lossMyoclonusDystoniaCognitive decline
From Orphanet’s phenotype annotations (CC BY 4.0). Not a complete list.
Treatments being studied
1 in clinical development, from Open Targets (CC BY 4.0). Not medical advice.
Phase 1/2Lithium Carbonate (Camcolit 250)
Before you apply
Things trial teams commonly ask about for Corticobasal Degeneration. Not eligibility rules; those are set by each study.
- Probable CBS diagnosis per Armstrong criteria is required — symptom asymmetry documentation is key
- FDG-PET or MRI showing asymmetric cortical and basal ganglia changes supports eligibility confirmation
- CSF and blood biomarkers (NfL, 4R-tau, phospho-tau) are used in trial stratification
- Anti-tau therapeutic trials (same pipeline as PSP) may accept CBS as a phenotypic variant — confirm if the trial is pathology-defined or syndrome-defined
Related conditions
Information, not medical advice. Trial listings are shown as recorded on ClinicalTrials.gov; whether any study is right for you is a decision for you and your clinicians, and eligibility is decided by each research team. Disease information from Orphanet (CC BY 4.0).