Rare condition

Neurotrophic keratopathy

ORPHA:137596 ↗

Search all Neurotrophic keratopathy trialsAlert me when a trial opens

studies recruiting now

as of 7 Sept 2026

studies registered in total

as of 7 Sept 2026

countries with a recruiting site

as of 7 Sept 2026

6 May 2026

most recent study posted

among recruiting studies

Recruiting trials

RecruitingPhase 4NCT07502378

Effect of Acoltremon Ophthalmic Solution 0.003% on Signs and Symptoms of Ocular Surface Disease in Stage I Neurotrophic Keratopathy Patients With Tear Deficiency

Sponsor University of South FloridaWhere United States (1 site)Studying Patients will receive topical Acoltremon 0.003% ophthalmic solution BID in both eyes over an 8 week period., Alternative would be patient exiting the trial and starting on tears or other standard of care.Updated 12 Aug 2026

See details

RecruitingNCT04700657

The Prevalence of Hypoesthesia Related Keratitis in Ocular Graft Vs. Host Disease (GVHD) Patients

Sponsor Indiana UniversityWhere United States (1 site)Studying corneal sensation testUpdated 12 Aug 2026

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RecruitingPhase 3NCT07519902

An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED

Sponsor Dompé Farmaceutici S.p.AWhere United States, Argentina, Czechia +11 (77 sites)Studying Cenegermin, VehicleUpdated 16 Jul 2026

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RecruitingPhase 2NCT07568730

A Multicenter, Randomized, Vehicle-Controlled, Double-Masked to Open-Label Study to Evaluate the Safety and Efficacy of Lacripep in Subjects With Neurotrophic Keratitis

Sponsor TearSolutions, Inc.Where United States (3 sites)Studying Lacripep, Vehicle Ophthalmic SolutionUpdated 11 May 2026

See details

RecruitingNot applicableNCT04604834

Autologous Platelet-rich Plasma (APRP) in the Treatment of Neurotrophic Keratopathy

Sponsor Universidad Autonoma de Nuevo LeonWhere Mexico (1 site)Studying PFAT first, APRP firstUpdated 6 May 2026

See details

Showing the 5 most recently updated recruiting studies, as recorded 7 Sept 2026. Live status on each study page.

See all 12 recruiting studies

Where recruiting studies are running

Countries with at least one recruiting site among the studies above, 7 Sept 2026. Tap a country to search trials there.

Argentina Czechia France Germany Hungary Italy Japan Mexico Netherlands Poland South Korea Spain United Kingdom United States

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Patient organisations

We do not yet list a dedicated organisation for this condition. The directories below are the best route.

NORD ↗GARD ↗Orphanet ORPHA:137596 ↗

About Neurotrophic keratopathy

RareTrial does not yet hold a plain-language description of this condition. The most reliable starting point is Orphanet’s expert page, which lists specialist centres, registries and patient organisations.

Orphanet expert page ↗GARD (NIH) ↗

Treatments being studied

2 approved treatments and 1 in clinical development, from Open Targets (CC BY 4.0). Not medical advice.

Approved: Cyclosporine (Capimune)Approved: Ex Vivo Expanded Autologous Human Corneal Epithelial Cells Containing Stem Cells (Holoclar)

Phase 2Spinosad (Comfortis)

Related conditions

Information, not medical advice. Trial listings are shown as recorded on ClinicalTrials.gov; whether any study is right for you is a decision for you and your clinicians, and eligibility is decided by each research team. Disease information from Orphanet (CC BY 4.0).