Rare condition

Generalized pustular psoriasis

ORPHA:247353 ↗Gene IL36RN Gene AP1S3

Search all Generalized pustular psoriasis trialsAlert me when a trial opens

10

studies recruiting now

as of 7 Sept 2026

67

studies registered in total

as of 7 Sept 2026

13

countries with a recruiting site

as of 7 Sept 2026

27 Apr 2026

most recent study posted

among recruiting studies

Recruiting trials

RecruitingPhase 2NCT07013201

A 16-week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream 20 mg/g in Adult Participants With Mild to Severe Palmoplantar Pustulosis

Sponsor LEO PharmaWhere United States, Canada, Germany +2 (39 sites)Studying Delgocitinib cream, Vehicle creamUpdated 31 Aug 2026

RecruitingPhase 3NCT07219420

A Study to Evaluate the Efficacy and Safety of Bimekizumab in Study Participants With Palmoplantar Pustulosis

Sponsor UCB Biopharma SRLWhere United States, Canada, China +10 (91 sites)Studying Bimekizumab, PlaceboUpdated 27 Aug 2026

RecruitingNCT06100991

CorEvitas Generalized Pustular Psoriasis (GPP) Drug Safety and Effectiveness Registry

Sponsor CorEvitasWhere United States (1 site)Updated 26 Aug 2026

RecruitingNot applicableNCT07552454

Picankibart in Palmoplantar Pustulosis

Sponsor Xijing HospitalWhere China (1 site)Studying PicankibartUpdated 27 Apr 2026

RecruitingPhase 4NCT07503652

Clinical Observation of Xeligekimab in the Treatment of Moderate to Severe Palmoplantar Pustulosis

Sponsor First Hospital of China Medical UniversityWhere China (1 site)Studying Xeligekimab InjectionUpdated 31 Mar 2026

Showing the 5 most recently updated recruiting studies, as recorded 7 Sept 2026. Live status on each study page.

See all 10 recruiting studies

Where recruiting studies are running

Countries with at least one recruiting site among the studies above, 7 Sept 2026. Tap a country to search trials there.

Canada China Czechia Denmark France Germany Hungary Italy Poland South Korea Spain United Kingdom United States

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Patient organisations

We do not yet list a dedicated organisation for this condition. The directories below are the best route.

NORD ↗GARD ↗Orphanet ORPHA:247353 ↗

About Generalized pustular psoriasis

RareTrial does not yet hold a plain-language description of this condition. The most reliable starting point is Orphanet’s expert page, which lists specialist centres, registries and patient organisations, and the genes involved (IL36RN, AP1S3).

Orphanet expert page ↗GARD (NIH) ↗

Treatments being studied

2 in clinical development, from Open Targets (CC BY 4.0). Not medical advice.

Phase 3Imsidolimab

Phase 3Spesolimab (Spevigo)

Related conditions

Information, not medical advice. Trial listings are shown as recorded on ClinicalTrials.gov; whether any study is right for you is a decision for you and your clinicians, and eligibility is decided by each research team. Disease information from Orphanet (CC BY 4.0).