Rare condition

Familial cold urticaria

ORPHA:47045 ↗Gene NLRP3

Search all Familial cold urticaria trialsAlert me when a trial opens

studies recruiting now

as of 7 Sept 2026

studies registered in total

as of 7 Sept 2026

countries with a recruiting site

as of 7 Sept 2026

5 Dec 2025

most recent study posted

among recruiting studies

Recruiting trials

RecruitingPhase 3NCT07266402

A Study to Investigate Efficacy, Safety and Tolerability of Barzolvolimab Versus Placebo in Adults With Cold Induced Urticaria and Symptomatic Dermographism Inadequately Controlled by H1-antihistamines (EMBARQ - ColdU and SD)

Sponsor Celldex TherapeuticsWhere United States, Germany, Lithuania +4 (72 sites)Studying Barzolvolimab, Matching PlaceboUpdated 26 Aug 2026

See details

RecruitingPhase 2NCT06865651

Study of Remibrutinib (LOU064) Efficacy and Safety and Exploration of Its Mechanism of Action in Participants With Chronic Urticaria

Sponsor Novartis PharmaceuticalsWhere United States, France, Germany +2 (17 sites)Studying Remibrutinib, PlaceboUpdated 19 Aug 2026

See details

RecruitingNCT06838143

Ilaris NIS in Korea

Sponsor Novartis PharmaceuticalsWhere South Korea (1 site)Studying IlarisUpdated 19 May 2026

See details

RecruitingNot applicableNCT06544018

Circadian Rhythm Deregulation in Patients With CAPS

Sponsor Hospices Civils de LyonWhere France (6 sites)Studying Genetic analysis of NLRP3, Circadian rhythm measurementUpdated 27 Feb 2026

See details

RecruitingPhase 1NCT07181369

A Phase 1 Study of GTX-B001 in Healthy Subjects and Patients With Chronic Inducible Urticaria

Sponsor Granular Therapeutics LimitedWhere Germany (2 sites)Studying GTX-B001, Normal SalineUpdated 30 Jan 2026

See details

Showing the 5 most recently updated recruiting studies, as recorded 7 Sept 2026. Live status on each study page.

Search all Familial cold urticaria studies

Where recruiting studies are running

Countries with at least one recruiting site among the studies above, 7 Sept 2026. Tap a country to search trials there.

France Germany Lithuania Poland South Africa South Korea Spain United Kingdom United States

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Patient organisations

We do not yet list a dedicated organisation for this condition. The directories below are the best route.

NORD ↗GARD ↗Orphanet ORPHA:47045 ↗

About Familial cold urticaria

RareTrial does not yet hold a plain-language description of this condition. The most reliable starting point is Orphanet’s expert page, which lists specialist centres, registries and patient organisations, and the gene involved (NLRP3).

Orphanet expert page ↗GARD (NIH) ↗

Treatments being studied

1 approved treatment and 1 in clinical development, from Open Targets (CC BY 4.0). Not medical advice.

Approved: Rilonacept (Arcalyst)

Phase 1Anakinra (Antril)

Related conditions

Information, not medical advice. Trial listings are shown as recorded on ClinicalTrials.gov; whether any study is right for you is a decision for you and your clinicians, and eligibility is decided by each research team. Disease information from Orphanet (CC BY 4.0).