RecruitingNCT06607471
Cardiovascular
Left Ventricular Noncompaction
Also known as LVNC, isolated LVNC, noncompaction cardiomyopathy
Left Ventricular Noncompaction is a structural cardiomyopathy characterised by a heavily trabeculated left ventricular myocardium with deep intertrabecular recesses, thought to result from arrest of the normal embryonic compaction process,
ORPHA:54260 ↗Gene MYH7Gene LMNAGene TAZPrevalence 0.05–0.3 per 100,000 (estimated; likely underdiagnosed)Onset Any age; congenital to adulthoodAutosomal dominant; X-linked (TAZ); de novo
3
studies recruiting now
as of 7 Sept 2026
8
studies registered in total
as of 7 Sept 2026
3
countries with a recruiting site
as of 7 Sept 2026
23 Sept 2024
most recent study posted
among recruiting studies
Recruiting trials
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Predictors of Risk in Left Ventricular Non-Compaction
Showing the 3 most recently updated recruiting studies, as recorded 7 Sept 2026. Live status on each study page.
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About Left Ventricular Noncompaction
Left Ventricular Noncompaction is a structural cardiomyopathy characterised by a heavily trabeculated left ventricular myocardium with deep intertrabecular recesses, thought to result from arrest of the normal embryonic compaction process, and associated with heart failure, ventricular arrhythmias, and thromboembolic events. The condition may occur in isolation or in association with congenital heart defects, neuromuscular diseases, or metabolic disorders, and can be inherited or sporadic. TAZ gene mutations cause Barth syndrome, a syndromic form presenting in infant males with LVNC, skeletal myopathy, neutropenia, and growth retardation.
Common clinical features
Heart failure with reduced or preserved ejection fractionPalpitations and ventricular arrhythmiasThromboembolic events including systemic embolism and strokeProminent left ventricular trabeculations on echocardiography or MRI (NC:C ratio >2.3)Conduction abnormalities and bundle branch blockExercise intolerance and fatigueSudden cardiac death riskIn Barth syndrome: skeletal muscle weakness and recurrent infections
From Orphanet’s phenotype annotations (CC BY 4.0). Not a complete list.
Before you apply
Things trial teams commonly ask about for Left Ventricular Noncompaction. Not eligibility rules; those are set by each study.
- Echocardiographic or cardiac MRI confirmation of LVNC using standardised criteria (e.g., Jenni or Petersen criteria) is required for enrolment; bring recent imaging with quantified trabeculation ratios.
- Genetic testing is recommended both for diagnosis and to identify co-inherited pathogenic variants (e.g., LMNA, MYH7) that influence prognosis and trial-specific eligibility.
- Anticoagulation status and thromboembolic history are relevant to trial safety criteria; report all prior embolic events and current anticoagulation therapy.
Related conditions
Information, not medical advice. Trial listings are shown as recorded on ClinicalTrials.gov; whether any study is right for you is a decision for you and your clinicians, and eligibility is decided by each research team. Disease information from Orphanet (CC BY 4.0).