About Landau-Kleffner Syndrome
Landau-Kleffner syndrome is a rare epileptic encephalopathy characterized by acquired verbal auditory agnosia (inability to understand spoken language) in children who had previously normal language development, associated with EEG abnormalities showing continuous spike-wave activity during slow-wave sleep (CSWS). Seizures are present in most but not all patients. The language regression may be partial or complete, and outcome is variable. Treatment with corticosteroids, IVIG, and antiseizure medications may partially restore language.
Common Clinical Features
Clinical Trial Eligibility Tips
What to know before applying to Landau-Kleffner Syndrome trials.
Prolonged overnight EEG documenting CSWS pattern is required for diagnosis and trial enrollment
Formal speech-language assessment documenting receptive language regression from normal baseline is required
Corticosteroid treatment history (response, duration, dosing) must be documented as it affects subsequent trial eligibility
Age at LKS onset and time from language regression to treatment affects language outcome and trial stratification
Patient Resources
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