Dermatological
Lamellar Ichthyosis
Also known as LI, non-bullous congenital ichthyosiform erythroderma, TGM1 ichthyosis
Lamellar ichthyosis is a rare autosomal recessive disorder of cornification characterised by widespread, plate-like scaling of the entire skin surface from birth. The condition results from mutations in genes encoding proteins essential for
0
studies recruiting now
as of 7 Sept 2026
8
studies registered in total
as of 7 Sept 2026
0
countries with a recruiting site
as of 7 Sept 2026
None
recruiting study posted to date
among recruiting studies
Recruiting trials
No recruiting trial found right now.
8 studies are registered for Lamellar Ichthyosis, but none was recruiting as of 7 Sept 2026. Here is what is still worth doing.
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About Lamellar Ichthyosis
Lamellar ichthyosis is a rare autosomal recessive disorder of cornification characterised by widespread, plate-like scaling of the entire skin surface from birth. The condition results from mutations in genes encoding proteins essential for epidermal barrier formation and lipid transport, particularly TGM1, which encodes transglutaminase 1. Affected individuals are typically born encased in a collodion membrane that sheds to reveal persistent generalised scaling, thickened skin, and variable erythroderma throughout life.
Common clinical features
From Orphanet’s phenotype annotations (CC BY 4.0). Not a complete list.
Treatments being studied
2 in clinical development, from Open Targets (CC BY 4.0). Not medical advice.
Before you apply
Things trial teams commonly ask about for Lamellar Ichthyosis. Not eligibility rules; those are set by each study.
- Trials often require confirmed genetic diagnosis via panel sequencing of ichthyosis genes (TGM1, ABCA12, ALOX12B, CYP4F22, NIPAL4) — obtain results before applying.
- Wash-out periods for systemic retinoids (acitretin, isotretinoin) are typically 4–8 weeks; discontinue and document prior use as most trials exclude concurrent retinoid therapy.
- Baseline assessments commonly include ISGA (Ichthyosis Severity Global Assessment) scoring and body surface area measurement — familiarise yourself with these scales to streamline screening visits.
Related conditions
Information, not medical advice. Trial listings are shown as recorded on ClinicalTrials.gov; whether any study is right for you is a decision for you and your clinicians, and eligibility is decided by each research team. Disease information from Orphanet (CC BY 4.0).