RecruitingEarly phase 1NCT06125847
Rare condition
Homozygous familial hypercholesterolemia
11
studies recruiting now
as of 7 Sept 2026
85
studies registered in total
as of 7 Sept 2026
15
countries with a recruiting site
as of 7 Sept 2026
15 May 2026
most recent study posted
among recruiting studies
Recruiting trials
RecruitingNCT07447648
Assessing the Impact of Intensification of Lipid Lowering Therapy With Guidelines-based Evinacumab Administration on Coronary Plaque Volumes Measured by Coronary Computed Tomography Angiography (CCTA) in Patients With Homozygous Familial Hypercholesterolemia (HoFH)
RecruitingPhase 2NCT07591298
Phase II Clinical Trial to Evaluate the Efficacy and Safety of SYH2070 Injection in Participants With Homozygous Familial Hypercholesterolemia
RecruitingPhase 3NCT06597006
Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia
RecruitingPhase 1NCT07491172
A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias
Showing the 5 most recently updated recruiting studies, as recorded 7 Sept 2026. Live status on each study page.
See all 11 recruiting studiesWhere recruiting studies are running
Countries with at least one recruiting site among the studies above, 7 Sept 2026. Tap a country to search trials there.
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Patient organisations
We do not yet list a dedicated organisation for this condition. The directories below are the best route.
About Homozygous familial hypercholesterolemia
RareTrial does not yet hold a plain-language description of this condition. The most reliable starting point is Orphanet’s expert page, which lists specialist centres, registries and patient organisations, and the genes involved (ABCG5, ABCG8, APOB, LDLRAP1, PCSK9, LDLR).
Treatments being studied
2 approved treatments and 11 in clinical development, from Open Targets (CC BY 4.0). Not medical advice.
Approved: Evinacumab (Evkeeza)Approved: Evolocumab (Repatha)
Phase 3Rosuvastatin
Phase 3Lerodalcibep
Phase 3Zodasiran
Phase 3Inclisiran
Phase 3Alirocumab (Praluent)
Phase 3Lomitapide (Lojuxta)
Phase 3Lomitapide Mesylate (Juxtapid)
Phase 2/3Tafolecimab
+ 3 more in development
Related conditions
Information, not medical advice. Trial listings are shown as recorded on ClinicalTrials.gov; whether any study is right for you is a decision for you and your clinicians, and eligibility is decided by each research team. Disease information from Orphanet (CC BY 4.0).