RecruitingNot applicableNCT07464093
Connective Tissue
Ehlers-Danlos Syndrome
Also known as EDS, hypermobile EDS, hEDS, classical EDS
Ehlers-Danlos syndrome describes a group of connective tissue disorders characterized by joint hypermobility, skin fragility, and tissue extensibility. Thirteen subtypes are recognized, each caused by different genetic defects in collagen o
ORPHA:98249 ↗Gene COL5A1/2Gene COL3A1Gene TNXBGene and others (hEDS gene unknown)Prevalence 1-9 per 100,000 (Orphanet)Onset Neonatal, Infancy, ChildhoodGenetic (various)
15
studies recruiting now
as of 7 Sept 2026
95
studies registered in total
as of 7 Sept 2026
4
countries with a recruiting site
as of 7 Sept 2026
26 Jun 2026
most recent study posted
among recruiting studies
Recruiting trials
RecruitingNCT07672210
PregnAncy-Related Aortic DISsEction in China
RecruitingNCT07637084
Photobiomodulation for Chronic Pain and Fatigue in Hypermobile Ehlers-Danlos Syndrome (PBM-SEDh-01)
RecruitingNCT07151274
Impact of Ehlers-Danlos Syndrome on Gynaecological Health
RecruitingNCT06546137
National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry
Showing the 5 most recently updated recruiting studies, as recorded 7 Sept 2026. Live status on each study page.
See all 15 recruiting studiesWhere recruiting studies are running
Countries with at least one recruiting site among the studies above, 7 Sept 2026. Tap a country to search trials there.
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About Ehlers-Danlos Syndrome
Ehlers-Danlos syndrome describes a group of connective tissue disorders characterized by joint hypermobility, skin fragility, and tissue extensibility. Thirteen subtypes are recognized, each caused by different genetic defects in collagen or extracellular matrix proteins. Hypermobile EDS (hEDS) is the most common but has no identified gene yet. Vascular EDS (COL3A1) carries the highest risk of arterial rupture and requires monitoring.
Common clinical features
Hyperextensible skinGeneralized joint laxityAtrophic scarsFragile skinSoft, doughy skinStriae distensaeCigarette-paper scarsMuscle spasm
From Orphanet’s phenotype annotations (CC BY 4.0). Not a complete list.
Before you apply
Things trial teams commonly ask about for Ehlers-Danlos Syndrome. Not eligibility rules; those are set by each study.
- EDS subtype must be confirmed using 2017 EDS International Classification criteria before most trials
- hEDS has the most trial activity since it is the most prevalent, but gene confirmation is not yet possible
- Comorbidities like POTS, MCAS, and chronic pain are often tracked as secondary endpoints
Related conditions
Information, not medical advice. Trial listings are shown as recorded on ClinicalTrials.gov; whether any study is right for you is a decision for you and your clinicians, and eligibility is decided by each research team. Disease information from Orphanet (CC BY 4.0).