About Common Variable Immunodeficiency
Common Variable Immunodeficiency is the most prevalent symptomatic primary antibody deficiency, characterized by markedly reduced serum immunoglobulin levels across all major classes and impaired vaccine responses. Affected individuals suffer recurrent bacterial infections, particularly of the respiratory tract, and are at elevated risk for autoimmune complications, granulomatous disease, and lymphoma. Diagnosis requires exclusion of secondary causes and demonstration of hypogammaglobulinemia persisting beyond age four with documented functional antibody failure.
Common Clinical Features
Clinical Trial Eligibility Tips
What to know before applying to Common Variable Immunodeficiency trials.
Trials often require documented IgG below 500 mg/dL and failure of at least two IgG subclasses; confirm current immunoglobulin replacement therapy details before screening
Autoimmune or granulomatous CVID subtypes may qualify for separate immunomodulatory trial arms — clarify your CVID phenotype with your immunologist
Prior splenectomy or active malignancy typically disqualifies participants; gather your full surgical and oncology history
Patient Resources
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