RecruitingPhase 3NCT07482085
Neurological
Creutzfeldt-Jakob Disease
Also known as CJD, sporadic CJD, variant CJD (vCJD), familial CJD
Creutzfeldt-Jakob disease is the most common human prion disease, caused by misfolding and aggregation of the prion protein (PrP) encoded by PRNP. Sporadic CJD (sCJD) accounts for ~85% of cases and arises spontaneously; familial CJD is caus
ORPHA:204 ↗Gene PRNPPrevalence 1-9 per 1,000,000 (Orphanet)Onset AdultPrion (sporadic, genetic PRNP mutation, or acquired)
4
studies recruiting now
as of 7 Sept 2026
15
studies registered in total
as of 7 Sept 2026
3
countries with a recruiting site
as of 7 Sept 2026
19 Mar 2026
most recent study posted
among recruiting studies
Recruiting trials
RecruitingPhase 1NCT07444580
PrP-targeting siRNA Safety & Mechanism Study
RecruitingNCT05124392
OBSERVE: Biomarkers in Individuals at Risk for Prion Disease
RecruitingNCT05746715
A Natural History Study of Preclinical Genetic Creutzfeldt-Jakob Disease (CJD)
Showing the 4 most recently updated recruiting studies, as recorded 7 Sept 2026. Live status on each study page.
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Countries with at least one recruiting site among the studies above, 7 Sept 2026. Tap a country to search trials there.
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About Creutzfeldt-Jakob Disease
Creutzfeldt-Jakob disease is the most common human prion disease, caused by misfolding and aggregation of the prion protein (PrP) encoded by PRNP. Sporadic CJD (sCJD) accounts for ~85% of cases and arises spontaneously; familial CJD is caused by PRNP mutations; variant CJD (vCJD) is linked to BSE ('mad cow disease') exposure. The disease causes rapidly progressive dementia, myoclonus, cerebellar ataxia, and visual disturbances, with death typically within 1 year of onset in sCJD.
Common clinical features
Rapidly progressive dementiaMyoclonusCerebellar ataxiaVisual disturbancesPeriodic sharp-wave complexes on EEG14-3-3 protein in CSFCortical ribboning on DWI MRI
From Orphanet’s phenotype annotations (CC BY 4.0). Not a complete list.
Before you apply
Things trial teams commonly ask about for Creutzfeldt-Jakob Disease. Not eligibility rules; those are set by each study.
- RT-QuIC assay on CSF is now the gold standard diagnostic test — positive result is required for most trial enrollment
- CJD subtype (sporadic, familial, variant) determines trial eligibility — PRNP genotyping (codon 129 MM/MV/VV) is required
- Rapidly progressive nature requires urgent trial contact — eligibility windows may be only weeks from symptom onset
- Brain MRI DWI pattern (cortical ribboning, basal ganglia signal) and EEG periodic sharp waves are required diagnostic documentation
Related conditions
Information, not medical advice. Trial listings are shown as recorded on ClinicalTrials.gov; whether any study is right for you is a decision for you and your clinicians, and eligibility is decided by each research team. Disease information from Orphanet (CC BY 4.0).