RecruitingNCT03109197
Cardiovascular
Brugada Syndrome
Also known as Right bundle branch block with ST elevation, Brugada pattern, SCN5A mutation
Brugada Syndrome is an inherited arrhythmia syndrome caused most frequently by loss-of-function mutations in SCN5A, encoding the cardiac sodium channel Nav1.
ORPHA:130 ↗Gene SCN5APrevalence 1 per 2,000; higher in Southeast Asian menOnset Typically identified in adulthood; mean age of sudden death around 40Autosomal dominant
11
studies recruiting now
as of 7 Sept 2026
56
studies registered in total
as of 7 Sept 2026
3
countries with a recruiting site
as of 7 Sept 2026
9 Aug 2024
most recent study posted
among recruiting studies
Recruiting trials
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Showing the 5 most recently updated recruiting studies, as recorded 7 Sept 2026. Live status on each study page.
See all 11 recruiting studiesWhere recruiting studies are running
Countries with at least one recruiting site among the studies above, 7 Sept 2026. Tap a country to search trials there.
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About Brugada Syndrome
Brugada Syndrome is an inherited arrhythmia syndrome caused most frequently by loss-of-function mutations in SCN5A, encoding the cardiac sodium channel Nav1.5, leading to a characteristic coved-type ST-segment elevation in the right precordial leads and a predisposition to ventricular fibrillation and sudden cardiac death, predominantly during rest or sleep. The syndrome is markedly more prevalent in males and in individuals of Southeast Asian ancestry, and fever is a well-recognised precipitant of arrhythmic events. Diagnosis requires the presence of a Type 1 Brugada ECG pattern either spontaneously or unmasked by sodium channel blockers.
Common clinical features
Type 1 coved ST-segment elevation in V1-V2 on ECGVentricular fibrillation or polymorphic ventricular tachycardiaSyncope, often nocturnal or at restSudden cardiac arrest as first presentation in some patientsFever-induced arrhythmia or unmasking of Brugada patternSupraventricular arrhythmias (atrial fibrillation)Asymptomatic pattern detected incidentally on ECGNocturnal agonal respiration (in family members witnessing events)
From Orphanet’s phenotype annotations (CC BY 4.0). Not a complete list.
Treatments being studied
2 in clinical development, from Open Targets (CC BY 4.0). Not medical advice.
Phase 3Hydroquinidine
Phase 3Amifampridine Phosphate (Amifampridine serb)
Before you apply
Things trial teams commonly ask about for Brugada Syndrome. Not eligibility rules; those are set by each study.
- A documented spontaneous or drug-induced Type 1 Brugada ECG pattern is the primary diagnostic criterion required for most trial enrolment; procainamide or ajmaline challenge records may be needed.
- Family history of sudden unexplained death and personal history of syncope or resuscitated cardiac arrest are important eligibility covariates; compile a detailed family pedigree.
- ICD implantation history and prior ablation procedures should be disclosed; some trials studying catheter ablation strategies may specifically recruit patients with symptomatic recurrences.
Related conditions
Information, not medical advice. Trial listings are shown as recorded on ClinicalTrials.gov; whether any study is right for you is a decision for you and your clinicians, and eligibility is decided by each research team. Disease information from Orphanet (CC BY 4.0).