About Behcet Disease
Behcet Disease is a systemic vasculitis of unknown etiology involving vessels of all sizes and characterized by the pathognomonic triad of recurrent oral aphthous ulcers, genital ulcers, and ocular inflammation, with additional potential involvement of the skin, joints, gastrointestinal tract, and central nervous system. Strong HLA-B51 association suggests an autoinflammatory mechanism, though the precise immunopathogenesis remains incompletely understood. The disease follows a relapsing-remitting course and can cause irreversible organ damage, particularly vision loss from uveitis and neurological deficits from neuro-Behcet.
Common Clinical Features
Clinical Trial Eligibility Tips
What to know before applying to Behcet Disease trials.
International Study Group diagnostic criteria fulfillment is typically required; compile documentation of ulcer frequency, eye exam reports, and pathergy test results
Uveitis trials often stratify by ocular involvement severity and prior biologic use (anti-TNF, interferon); have complete ophthalmology records and visual acuity measurements available
Active major vessel disease (arterial aneurysm, venous thrombosis) may require separate anticoagulation management and can affect trial eligibility — disclose vascular history fully
Patient Resources
Find recruiting Behcet Disease trials
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